QSAR of anti-inflammatory drugs

QSAR of anti-inflammatory drugs

The computer analysis of relations between molecular structures and their biological activity using fragmentbased methods is very useful to draw conclusions for the understanding of drug action and for the development of more efficient non-toxic drug candidates. We used the computer system SARD-21 (Structure Activity Relationship & Design) to investigate common structural features (fragments an...

Anti-Inflammatory Activity of a Selection of Antidepressant Drugs

      Anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. In this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory d...

Nonsteroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...

Non-steroidal anti-inflammatory drugs.

Anti-inflammatory drugs in psychiatry.

Nervous and immune system interact through many different messenger substances such as neurotransmitters, cytokines or neuropeptides. For instance, neuropeptides are capable of affecting the metabolism of cells belonging to the immune system. Conversely, cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-alpha and IFN-gamma, contribute to the receptor resistance of neuropepti...